Hepatitis B virus-mediated sodium influx contributes to hepatic inflammation via synergism with intrahepatic danger signals
Summary: The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome has been involved in the pathogenesis of various chronic liver diseases.However, its role in hepatitis B virus (HBV)-associated hepatitis remains unknown.Here we demonstrate the synergistic effect of HBV with potential intrahepatic danger signals on NLRP3 inflammasom